Endocrine Abstracts

Introduction: Several genetic syndromes are associated with familial pituitary adenomas. The penetrance of clinical manifestations of these syndromes is not ubiquitous and this might be the reason for the lack of detection of genetic mutations when only one or few genes are studied.Aim: Clinical characterisation and molecular genetic study of a panel with ten genes involved in formation of pituitary adenomas in familial setting.Mat...

A 27-year-old male patient during past 10 years noted a gradual change in his appearance, but began to seek a medical attention only 1.5 years ago due to reduced vision. Hormonal tests from March 2013 revealed marked elevation of GH to 106 mIU/ln (ref. values <20), and IGF1 to 567 ng/ml (121–336), decrease in testosterone levels to 1.91 ng/ml (3–12), with cortisol, LH, FSH, PRL, TSH values within the reference range; MRI of the brain showed a 4×7 mm adenoma ...